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Hesperidin is a bioflavonoid found in high concentration in citrus fruits. In addition to its well-known benefits for cardiovascular function, type II diabetes, and anti-inflammation, recent studies have demonstrated the multiple benefits of hesperidin for cutaneous functions, including wound healing, UV protection, anti-inflammation, anti-microbial, skin cancer prevention, and skin lightening. Because of its low cost, wide availability, and superior safety, hesperidin could prove useful for the management of a variety of cutaneous conditions. However, a limiting factor of hesperidin is its water solubility.